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Anticardiolipin Antibody (IgG, IgM, IgA)

Justification

Anticardiolipin (ACL) antibodies are associated with antiphospholipid syndrome (APS). Persistently elevated levels of ACL antibodies are associated with an increased risk of vascular thrombosis and obstetrical complications.

STAT: < 48 hours (M-F)

ELISA

Draw Tube: Red Top

Sample Type: Serum

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Serum 1mL 0.5mL Room Temp.: 7 days
Refrigerated: 14 days
Frozen (-20C): 1 month
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY ELISA
STAT TAT < 48 hours (M-F)
STAT TAT Performance > 90% of results released in 48 hours
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES ACL, cardiolipin antibodies
DESCRIPTION This assay employs an FDA-approved, ELISA method and reports in GPL, MPL or APL units.
LIMITATIONS -
NORMAL RANGE IgG <15 GPL, IgM <12.5 MPL and IgA <12 APL
ASSOCIATED TESTING -
REFERENCES

1. Miyakis et al. International consensus statements on an update of the classification criteria for definite APS. J Thromb Haemost 2006, 4:295-306.
2. Harris et al. Anticardiolipin and Lupus Anticoagulant Testing and Significance. J Clin Immunoassay 1994, 17(2): 1-10.
3. Shen et al. IgA antiphospholipid antibodies are an independent risk factor for thrombosis. Lupus 2008, 17:996-1003.
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED Yes

Test Codes

ORDER CODE P3027
CPT CODE 86147x3
LOINC CODE 3181-5, 3182-3, 5076-5