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Antiphosphatidylserine Antibody (IgG, IgM)

Justification

The detection of anti-phosphatidylserine antibodies has been recommended for the serological diagnosis of antiphospholipid syndrome (APS). Antiphosphatidylserine antibodies have been associated with an increased risk for recurrent arterial and venous thrombotic events, thrombocytopenia and fetal loss.

STAT: < 48 hours (M-F)

ELISA

Draw Tube: Red Top

Sample Type: Serum

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Serum 1mL 0.5mL Room Temp.: 7 days
Refrigerated: 14 days
Frozen (-20C): 1 month
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit if shipped frozen, refrozen, clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY ELISA
STAT TAT < 48 hours (M-F)
STAT TAT Performance > 90% of results released in 48 hours
ROUTINE TAT < 1 week
ALTERNATIVE NAMES APS
DESCRIPTION Chromogenic ELISA for the quantitative determination of IgG and IgM antibodies to phosphatidylserine in human plasma.
LIMITATIONS -
NORMAL RANGE IgG <16 GPS unitsIgM <22 MPS units
ASSOCIATED TESTING -
REFERENCES

1.American Society of Clinical Pathologists. Tech Sample, “Antiphospholipid Antibody Syndrome”, Hematology #H-4, 1994.
2.Coleman, Hirsh et al “Hemostasis and Thrombosis: Basic Principles and Clinical Practice” 4th edition Lippincott pg. 1339-1347,2001
3.REAADS Corgenix “Anti-Phosphatidylserine Semi8 Quantitative Test Kit” package insert. Corgenix Inc. 2002 Westminister, Colorado, 2009. Dec 2014 no procedural changes.
4.Rodger L.B. M.D. and William F. Baker, M.D. “Antiphospholipid and Thrombosis Syndromes”, Seminars in Thrombosis and Hemostasis, Vol 20 # 1, 1994.
5.Williams, Beutler et al, “Williams Hematology” 5th edition McGraw-Hill, pg. 193-194, 1995.
6.Hughes Syndrome: Antiphospholipid Syndrome, INOVA Diagnostics Inc, Springer 2nd edition 2006.
7.Henry’s Clinical Diagnosis and Management by Laboratory Methods, McPherson et al, Elsevier Saunders, 22nd Edition, 2011.
8.Hemostasis and Thrombosis: Basic Principle and Clinical Practice, Robert Coleman et al, Lippincott Williams and Wilkins, 5th edition, 2006.
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED No

Test Codes

ORDER CODE P3301
CPT CODE 86148x3
LOINC CODE 32032-5, 32033-3