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Antithrombin III Activity

Justification

Antithrombin III (ATIII) is a glycoprotein inhibitor of thrombin and factor Xa, whose activity is greatly potentiated by heparin. ATIII deficiencies are associated with a high risk of venous thromboembolic disease. Approximately 55 percent of patients with AT deficiency who have a family history of venous thromboembolism experience venous thrombotic episodes by the age of 50.

STAT: < 24 hours (7 days a week)

Chromogenic

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma 1mL 0.5mL Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Chromogenic
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES ATIII Activity, AT3 Activity
DESCRIPTION Chromogenic assay for the quantitative determination of ATIII activity in human plasma.
LIMITATIONS -
NORMAL RANGE 86-122%
ASSOCIATED TESTING -
REFERENCES

Mackie M, Bennett B, Ogston D, Douglas AS. Familial thrombosis: inherited deficiency of antithrombin III. Br Med J 1978; 1:136.
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED -

Test Codes

ORDER CODE P3036
CPT CODE 85300
LOINC CODE 27811-9