Factor II (2) Activity - Machaon Diagnostics

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Factor II (2) Activity

Justification

Deficiencies in Factor II (Prothrombin) Activity are associated with excessive bleeding, including easy bruising, frequent nose bleeds, menorrhagia, and/or hemorrhaging during or after surgery, trauma, or childbirth. Joint bleeding is uncommon. Acquired Factor II deficiency due to coumadin anticoagulation, vitamin K deficiency, severe liver disease, or other causes is more common than congenital or inherited Factor II deficiency which is estimated to occur in 1 out of every 2 million people.

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

	Sample Type	Volume Required	Minimum Volume	Stability
PREFERRED	Citrated Plasma	1mL	0.5mL	Frozen (-20C): 2 weeks Frozen (-80C): 6 months
ALTERNATIVE	-	-	-	-

REJECTION CRITERIA	Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS	-

General Information

METHODOLOGY	Clot-based
STAT TAT	< 24 hours (7 days a week)
STAT TAT Performance	> 90% of results released in 24 hours 7 days a week
ROUTINE TAT	< 3 days (M-F)
ALTERNATIVE NAMES	Prothrombin Activity, F2, FII
DESCRIPTION	This is a clot-based assay for the determination of Factor II Activity level in citrated plasma. Patient sample at three different dilutions is mixed with Factor II Deficient plasma containing normal levels of all other factors, such that the resulting Prothrombin Time is dependent only on the level of Factor II present in the patient sample. This value is compared to a reference curve generated from calibrators with known levels of Factor II Activity.
LIMITATIONS	-
NORMAL RANGE	85-142%
ASSOCIATED TESTING	-
REFERENCES	-
SAMPLE REPORT	Upon request
NEW YORK STATE APPROVED	No

Test Codes

ORDER CODE	P3047
CPT CODE	85210
LOINC CODE	3289-6