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Factor XI (11) Activity

Justification

Hemophilia C, or Rosenthal Syndrome, is caused by congenital deficiency of Factor XI. Deficiencies in Factor XI may also be acquired secondary to other diseases such as liver disease, disseminated intravascular coagulation (DIC), or the development of a specific factor inhibitor.

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma 1mL 0.5mL Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Clot-based
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES Plasma Thromboplastin Antecedent, F11, FXI
DESCRIPTION This is a clot-based assay for the determination of Factor XI Activity level in citrated plasma. Patient sample at three different dilutions is mixed with Factor XI Deficient plasma containing normal levels of all other factors, such that the resulting activated Partial Thromboplastin Time is dependent only on the level of Factor XI present in the patient sample. This value is compared to a reference curve generated from calibrators with known levels of Factor XI Activity.
LIMITATIONS -
NORMAL RANGE 60-152%
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED No

Test Codes

ORDER CODE P3058
CPT CODE 85270
LOINC CODE 3226-8