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Fibrinogen Activity

Justification

Fibrinogen, a glycoprotein synthesized primarily in the liver, is one of the primary structural components of a clot, assembling into fibrin strands upon cleavage by thrombin (FIIa). Fibrinogen is an acute phase reactant and increased fibrinogen activity levels may be found in cases of diabetes, inflammatory syndromes, and obesity. Decreased fibrinogen activity levels may be hereditary (afibrinogenemia, hypofibrinogenemia, or dysfibrinogenemia) or occur secondary to DIC, fibrinolysis, hemorrhage, and other causes. Furthermore, fibrinogen seems to be involved in the pathogenicity of thrombotic cardiovascular events.

STAT: < 24 hours (7 days a week)

Clauss, Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma 1mL 0.5mL Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Clauss, Clot-based
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES Factor I, F1, FI
DESCRIPTION In the presence of an excess of thrombin, the clotting time of a diluted plasma has a direct bearing on the level of plasma fibrinogen.
LIMITATIONS -
NORMAL RANGE 170-410 mg/dL
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED Yes

Test Codes

ORDER CODE P3064
CPT CODE 85384
LOINC CODE 3255-7