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PT Mixing Study

Justification

Mixing studies are performed to determine whether prolongations in coagulation screening tests are due to coagulation factor deficiencies or the presence of an inhibitor. This can help direct further follow-up testing.

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma Two aliquots, 1mL each Two aliquots, 0.5mL each Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Clot-based
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 24 hours (M-F)
ALTERNATIVE NAMES -
DESCRIPTION PT is performed on a mixture of patient and normal pooled plasma. If the prolonged PT corrects upon immediate mixture with normal pooled plasma, follow up with specific factor activity assays. If the prolonged PT fails to correct upon immediate mixture with normal pooled plasma, assess for the presence of an inhibitor or anticoagulant.
LIMITATIONS -
NORMAL RANGE Interpretation
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED -

Test Codes

ORDER CODE P3078
CPT CODE 85610, 85611
LOINC CODE 5902-2, 6301-6, 5959-2, 33356-7