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von Willebrand Factor Multimer

Justification

The basic subunit of von Willebrand Factor (VWF) is a protein of molecular weight 230,000 daltons. A protomer, consisting of two of these subunits, is the basic unit which forms multimers by means of inter-dimer disulfide bonds. A heterogeneous collection of these multimers ranging in size from 500,000 daltons to over 10,000,000 daltons (species of over 20 subunits) is required for normal platelet trafficking. VWF Multimer testing should be ordered as part of a von Willebrand Disease workup for the detection and differentiation of Type 2 VWD. Specific subtypes of Type 2 VWD are characterized by the absence of the highest molecular weight multimers.

STAT: < 1 week

Electrophoresis

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma 1mL 0.5mL Room Temp.: 2 hours
Refrigerated: 2 hours
Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Electrophoresis
STAT TAT < 1 week
STAT TAT Performance > 90% of results released in 1 week
ROUTINE TAT < 1 week
ALTERNATIVE NAMES VWF Multimeric Analysis, VWF Multimer, MULT
DESCRIPTION Western blot for the separation and visualization of von Willebrand Factor Multimers.
LIMITATIONS -
NORMAL RANGE Normal
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED -

Test Codes

ORDER CODE P3120
CPT CODE 85247
LOINC CODE 6013-7