Plasminogen Activator Inhibitor Activity (PAI-1) Gene Sequencing

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STAT: < 48 hours (M-F)

NGS

Draw Tube: Purple Top

Sample Type: EDTA Whole Blood

DRAW KITS AVAILABLE

	Sample Type	Volume Required	Minimum Volume	Stability
PREFERRED	EDTA Whole Blood	3mL	1mL	Room Temp.: 1 month Refrigerated: 1 month
ALTERNATIVE	Cheek swab	2 swab	-	Room Temp.: 1 month Refrigerated: 1 month

REJECTION CRITERIA	Sample contamination; sample compromised
SPECIAL INSTRUCTIONS	-

METHODOLOGY	NGS
STAT TAT	< 48 hours (M-F)
STAT TAT Performance	> 90% of results released in 48 hours
ROUTINE TAT	< 5 days (M-F)
ALTERNATIVE NAMES	SERPINE1 gene sequencing, PAI-1 sequencing
DESCRIPTION	This test sequences the exons plus 5bp of the flanking introns of the SERPINE1 gene. Note, this sequencing assay does not cover the 4G/5G promoter polymorphism; this polymorphism has been associated with thrombotic risk but is also very common (25-50% of the normal population carry the risk allele). Sanger sequencing may be used to confirm variants as needed.
LIMITATIONS	This test will not detect variants located outside of the targeted DNA regions. This test is not optimized to detect chimerism or somatic mosaicism. This test will detect small indels but may miss larger deletions or duplications. Balanced structural variants will not be detected unless specifically targeted by a custom PCR assay.
NORMAL RANGE	Interpretation: Negative
ASSOCIATED TESTING	-
REFERENCES	-
SAMPLE REPORT	Upon request
NEW YORK STATE APPROVED	No