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C3 Nephritic Factor

Justification

C3 Nephritic Factor is an autoantibody. It stabilizes C3 convertase. C3 Nephritic Factor is associated with approximately 80 percent of patients with DDD; it is also seen in approximately 40 percent of C3GN patients. It's not specific; however, detection of C3 Nephritic Factor supports the diagnosis of C3GN or DDD.

STAT: < 1 week

Ratio

Draw Tube: Red Top

Sample Type: Serum

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Serum 1mL 0.5mL Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Ratio
STAT TAT < 1 week
STAT TAT Performance > 90% of results released in 1 week
ROUTINE TAT < 1 week
ALTERNATIVE NAMES C3Nef
DESCRIPTION This is not a direct measurement of antibody quality, but only a qualitative (indirect) measure of its activity in causing C3 conversion.
LIMITATIONS -
NORMAL RANGE -
ASSOCIATED TESTING -
REFERENCES

Ito N, Ohashi R, et al, C3 glomerulopathy and current dilemmas, Clin Exp Nephrol 2017(4): 541-551
Du Clos T, Mold C, Complement in host deficiencies and diseases, Clinical Immunology 2013: 252-269
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED No

Test Codes

ORDER CODE P3366
CPT CODE 86161
LOINC CODE 23844-4