Dysfibrinogenemia Functional Panel

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Fibrinogen Activity Thrombin Time aPTT Prothrombin Time (PT/INR)

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

	Sample Type	Volume Required	Minimum Volume	Stability
PREFERRED	Citrated Plasma	Three aliquots, 1mL each	Three aliquots, 0.5mL each	Frozen (-20C): 2 weeks Frozen (-80C): 6 months
ALTERNATIVE	-	-	-	-

REJECTION CRITERIA	Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS	-

METHODOLOGY	Clot-based
STAT TAT	< 24 hours (7 days a week)
STAT TAT Performance	> 90% of results released in 24 hours 7 days a week
ROUTINE TAT	< 1 week
ALTERNATIVE NAMES	Fibrinogen panel
DESCRIPTION	The clot-based and ELISA-based tests in this panel are designed to be sensitive to fibrinogen disorders including dysfibrinogenemia, hypofibrinogenemia, hypodysfibrinogenemia and afibrinogenemia. In order to confirm the absence of heparins or DTIs, the thrombin time test reflexes to a heparin neutralization test when prolonged.
LIMITATIONS	-
NORMAL RANGE	Interpretation: Normal
ASSOCIATED TESTING	-
REFERENCES	1. Medved L et al. Fibrinogen and Factor XIII Subcommittee of Scientific Standardization Committee of International Society on Thrombosis and Haemostasis. Recommendations for nomenclature on fibrinogen and fibrin. J Thromb Haemost 2009; 7:355. 2. Tennent GA et al. Human plasma fibrinogen is synthesized in the liver. Blood 2007; 109:1971. 3. Martinez J. Congenital dysfibrinogenemia. Curr Opin Hematol 1997; 4:357. 4. Collen D et al. Metabolism and distribution of fibrinogen. I. Fibrinogen turnover in physiological conditions in humans. Br J Haematol 1972; 22:681.
SAMPLE REPORT	Upon request
NEW YORK STATE APPROVED	No