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Factor VII (7) Activity

Justification

Congenital deficiency of Factor VII (Alexander's Disease) is a rare inherited disorder that causes in general mild bleeding. Deficiencies in Factor VII activity may also be acquired secondary to other diseases such as liver disease, disseminated intravascular coagulation (DIC), vitamin K deficiency, or the development of a specific factor inhibitor.

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma 1mL 0.5mL Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Clot-based
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES Proconvertin, F7, FVII
DESCRIPTION This is a clot-based assay for the determination of Factor VII Activity level in citrated plasma. Patient sample at three different dilutions is mixed with Factor VII Deficient plasma containing normal levels of all other factors, such that the resulting Prothrombin Time is dependent only on the level of Factor VII present in the patient sample. This value is compared to a reference curve generated from calibrators with known levels of Factor VII Activity.
LIMITATIONS -
NORMAL RANGE 71-152%
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED No

Test Codes

ORDER CODE P3052
CPT CODE 85230
LOINC CODE 3198-9