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Lupus Anticoagulant Index

Justification

The lupus anticoagulant index has been shown to be sensitive to weak lupus anticoagulants. The presence of antiphospholipid antibodies, such as lupus anticoagulant, increases the risk of arterial thrombosis, venous thrombosis, thrombocytopenia and recurrent miscarriage. Lupus anticoagulants result in the prolongation of clotting times which correct with the addition of phospholipids.

STAT: < 24 hours (7 days a week)

Ratio, clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma 1mL 0.5mL Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Ratio, clot-based
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES LAX
DESCRIPTION Comparison of activated partial thromboplastin time using a lupus sensitive reagent and a lupus insensitive reagent. A lupus anticoagulant index of 10% or less is considered negative for lupus anticoagulant. A lupus anticoagulant index of 15% or more is considered positive.
LIMITATIONS -
NORMAL RANGE Negative, ≤ 10%
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED -

Test Codes

ORDER CODE P3074
CPT CODE 85730x2
LOINC CODE 34571-0, 52751-5