Platelet Aggregation - Aspirin Sensitivity

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Platelet Aggregation – Aspirin Sensitivity

Justification

Aspirin (acetylsalicylic acid) is commonly prescribed as an antiplatelet agent for the prevention of arterial thrombosis in conjunction with Plavix. Aspirin is a COX-1 inhibitor and reduces the production of thromboxane A2 (TXA2), a vasoconstrictor and activator of platelets, in activated platelets, interrupting the positive feedback loop. Aspirin sensitivity testing by platelet aggregometry can be used to assess the effectiveness of platelet inhibition by aspirin therapy or restoration of platelet function after discontinuation of aspirin.

STAT: < 24 hours (M-F)

Light Transmittance Aggregometry (LTA)

Draw Tube: Blue Top

Sample Type: Citrated Whole Blood

Specimen Requirements

	Sample Type	Volume Required	Minimum Volume	Stability
PREFERRED	Citrated Whole Blood	Four tubes, 3mL each (or equivalent volume)	For pediatric minimum, please call (800) 566-3462.	Room Temperature: 4 hours By appointment only - must arrive at lab within 2 hours of draw
ALTERNATIVE	-	-	-	-

REJECTION CRITERIA	Samples received more than 2 hours after draw
SPECIAL INSTRUCTIONS	See Draw Guide By appointment only

General Information

METHODOLOGY	Light Transmittance Aggregometry (LTA)
STAT TAT	< 24 hours (M-F)
STAT TAT Performance	> 90% of results released in 24 hours
ROUTINE TAT	< 24 hours (M-F)
ALTERNATIVE NAMES	Platelet Aggregation - ASA, Aspirin Sensitivity
DESCRIPTION	Platelet aggregation is measured in response to Arachidonic Acid and control agonists by light transmittance aggregometry (LTA). A significant reduction in platelet aggregation in response to Arachidonic Acid is expected with successful aspirin therapy.
LIMITATIONS	Hemolytic, Icteric, and Lipemic samples
NORMAL RANGE	Interpretation
ASSOCIATED TESTING	-
REFERENCES	-
SAMPLE REPORT	Upon request
NEW YORK STATE APPROVED	-

Test Codes

ORDER CODE	P3029
CPT CODE	85576x4
LOINC CODE	53568-2