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Platelet Electron Microscopy

Justification

Platelet electron microscopy is considered a gold standard test for detecting ultrastructural abnormalities in inherited platelet disorders, such as dense granule (delta) storage pool deficiency due to acquired and inherited causes. For maximum sensitivity, this test should be ordered in conjunction with platelet aggregation studies.

STAT: < 2 weeks

Electron Microscopy

Draw Tube: Yellow Top

Sample Type: ACD Whole Blood

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED ACD Whole Blood Two tubes, 8mL each 7mL Room Temperature: 48 hours
Monday-
Thursday, 8am-2pm only - must arrive at lab within 24 hours of draw
ALTERNATIVE - - - -
REJECTION CRITERIA Samples received more than 24 hours after draw or after 2pm Thursday
SPECIAL INSTRUCTIONS Either ACD-A and ACD-B tubes can be submitted so long as a minimum of 7mL of whole blood is submitted.

General Information

METHODOLOGY Electron Microscopy
STAT TAT < 2 weeks
STAT TAT Performance > 90% of results released in 2 weeks
ROUTINE TAT < 2 weeks
ALTERNATIVE NAMES Platelet EM
DESCRIPTION Transmission electron microscopy (TEM) examination of whole mounted platelets and enumeration of dense granules within each platelet.
LIMITATIONS -
NORMAL RANGE 4-6 DG/PL
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED -

Test Codes

ORDER CODE P3348
CPT CODE 88348
LOINC CODE 79768-8